[Solved!] SSRI-induced sexual dysfunction

MrNeurotypical Nov 2, 2018

MrNeurotypical Nov 2, 2018

This is what worked for me, YMMV. Background: I took fluoxetine(prozac) and after 1 week had anorgasmia and erectile dysfunction. I kept taking it for a total of 1 month. I was also on trazadone at the same time. After 1 month I discontinued both drugs. I had my prolactin measured before and after 3 weeks on SSRIs. It increased 61% from 5.9 to 9.5. I'm on TRT so I know exactly what my testosterone, estrogen, CBC, etc are. Solution:
Discontinue SSRIs Reduce Prolactin: I took vitex agnus-castus to reduce prolactin(another option is cabergoline) Increase dopamine/NO/etc: These did the trick, but none worked by themselves: yohimbine, green tea extract, methylfolate, pregnenolone.
I've been off SSRIs for 2.5 weeks and finally had a decent erection and orgasm for the first time in 5.5 weeks. I tried yohimbine alone and pregnenolone alone but it didn't work. I don't know the exact mechanisms of all these supplements but it was like a switch going on, just like it was like a switch going off when SSRIs induced it. Perhaps there's a tipping point for all these neurotransmitters and once you cross the line everything works fine.