A few months ago, I trialed doing a test e cycle to fix my pssd. It worked.

Sure, Test e is testosterone ethanate. It’s generally used only for men. I inject it into my delts twice a week via a needle with the dosages I mentioned. The weekly dosage totalling 500, so 250 each pin. The test e shuts down your natural test production and your fertility and some other hormones. After my cycle is complete, I waited 3 weeks for the test e to leave my body. And then I started pct post cycle therapy to kick start my hormones and natural production again. I’m not sure why it is so effective but i feel better than before I even started zoloft. Feels weird suddenly having sensitivity and morningg wood again. It is very important you stay on top of blood work constantly as test e even though considered safe and a beginner cycle can have very severe side effects.

Thanks for the update. What dosage and for how long were you on Zoloft?

50mg bumped to 100 half way through. For over 12 months. I don’t remember exact timeline but it was 12 months possibly up to 14

Did you have a doctor monitoring your total and free T? If so, could you share what it was during the trial?

He wasn’t monitoring per say but I was getting regular checkups every 4 weeks. One thing I did have prior was elevated prolactin levels post ssri

Oh so you never actually had your test measured?

Sorry yes I did, it was around 600 off the top of my head. Everything was “healthy” levels

One last question: could you describe the positive effects while on testosterone? Or are you saying you didn’t get libido recovering until 3 weeks after you stopped?

That’s the weird thing, everyone mentioned the massive sex drive that comes along it but for me it was barely noticeable. It was definitely an improvement but not much. Pct changed everything though. After pct I was back to normal, actually I felt the effects 1 week into pct

So weird. Is it possible that a “PCT” cycle alone could do the trick? If so, I wonder what within the “PCT” stack is the real “resetting” agent. You said you have perused a bunch of literature I believe, on PSSD - any ideas come to mind?

Based of what I read, and even experienced I think the “shutdown” and “reboot” was the trick. I can’t say anything based on pct alone. It may even be a little dangerous if taken while your hormones and test is at a normal level.

How did you come up with this idea?

I didnt, I read online and other peoples stories doing similar things and yelling results. I was pretty desperate so I gave it a go.

Did you do this under guidance of a doctor? If so who was your doctor? If I tried something like this I'd want to do it with medical supervision.

No guidance, I had very experienced bodybuilders guide me and did get all necessary blood work done prior, during and currently waiting another week or two to get my post cycle bloods done. But I really even “feel” alive again. I don’t have that numb feeling when I was off Zoloft. Where everything looked and felt grey. It’s hard to describe. But I can “feel” again.

Great man really happy for you ! I have some questions. First of all my current issues are severe Ed and zero libido . Did you also have severe Ed and low libido and did this help you recover ?

Yes had bad ED, almost non existent libido. I went from a typical teenager libido to a grandpa. This helped bring it back to what “normal” used to be for me

Years ago when going from doc to doc and ended up with a neurologist who did test my T levels and said they were fine. How were yours before you did this?

My test levels were totally fine. I had a slightly elevated prolactin level but everything else was in check.

How long did you have pssd before doing this treatment?

Over 8 months

Happy to hear, that you are fine now. :-) What were your PSSD symptoms? Do you think the cure is permanent? When did you finish pct?

Typical, depressed, no joy in things that used to make me happy or excited, obviously ed, loss of sensitivity. I finished pct about 2 weeks ago. I hope it’s permanent. I will update this sub in a few months properly if it’s still working.

I tested testosterone and it gave me windows, I hope to try again with supra physiological doses. It's very strange that you get better with post-cycle therapy, as it only serves to boost your natural testosterone production. For those who don't know post-cycle therapy is used after cycles with high doses of testosterone, you need to do tpc because when you give high doses of testosterone to your body, your body stops naturally producing testosterone. So with tpc you stimulate your body to produce again. However, I find it very strange that the improvement has been given to post-cycle therapy, since natural testosterone stimulators are extremely weak compared to injectable testo doses. I believe that something has returned to work due to the very high amount of testo in your body and brain. I've already tested clomid last year, to be honest it was the first thing I did when I discovered pssd, I had windows with testosterone too, after a few weeks I started to feel libido coming back, it came and went a few times a day. However, I stopped the treatment on the advice of my doctor. I will test testo at high doses in the future.

While I was on test e, things improved but they were not great. It only became “normal” once I got off, gave myself a 3 weeks break (which in hindsight should have been closer to 5) and then hit pct. Even during pct I felt better than ever.

Let me chime in and add some clarity to this guy’s experience/recovery. I’ve suffered from PFS for 11 years, which is in the same symptom category as PSSD and PAS. I too will soon be experimenting with a similar recovery attempt. Based on the current prevailing theory, SSRI’s, Accutane, and 5-AR inhibitors like Fin/Dut all disrupt the sensitivity of our androgen receptors at the epigenetic level. The resulting condition can be extremely persistent. However, there are many anecdotes out there like this of high doses of androgens curing people. I do not think it’s the reboot itself that cures this condition…there are tons of guys with PFS, etc. like me who begin TRT doses of testosterone and get very little or no relief. The problem: not enough androgens to “reset” the receptors. These dysfunctional ARs must be “overwhelmed” with androgens in order to reset their sensitivity levels back to normal. So, most guys cannot simply go on TRT doses and then clomid and expect a full recovery. It seems to require BB doses of T and/or DHT compounds to combat this…and it may take more than one of these steroid cycles to fully recover. This type of protocol is obviously not without risk. Whoever tries this needs to be extremely careful/informed about how to conduct such cycles in the safest way possible.

did you took an aromatase inhibitor? and please share your hcg regime too. thx

I didn’t have to. I did get sensitive nipples but took 12.5mg ai once or twice during the whole course. I posted the hcg regime above

Your testo levels were normal? My testo is high right now, i not have sure if this could help

They were normal yes.

Would it be possible for you to write up in detail how you did this, what doctor you were able to work with, and keep us updated if the progress is permanent (I really hope so for your sake and ours) even after you finish PCT. A lot of people leave after they treat their PSSD but I'd really like to know. How long did you have PSSD for? I've had it for 14 years (since 2007) when I took Effexor and then Zoloft for about 1.5 years total. I kind of gave up for a while but have seen multiple reports from different redditors of TRT + PCT resetting their system. This is kind of what we are all hoping for. Is there any doctor who would want to do a research report on this? I know there is a medical student who writes in these forums sometime. It might be good to get a clinical trial setup for PSSD for such a treatment cycle since it seems to have worked for multiple people.

I didn’t work with a doctor, I was lucky enough to have “contacts” in the bodybuilding industry that could source pharmacy grade test and pct. Be very very careful you don’t get homelab made test as they aren’t dosed correct and can do some serious damage. You can go to a performance clinic, they can help and prescribe test, hgh, really anything. They don’t judge like your typical gp’s. I was on Zoloft for almost 13 months and it fucked me for 8 months. I said fuck this went on test and after pct I’m back to normal. During test I did not feel that much better mind you, but I did stick with it. And followed it strictly to the t

armacy grade test and pct. Be very very careful you don’t get homelab made test as they aren’t dosed correct and can do some serious damage. You can go to a performance clinic, they can

This is good to know. This route makes me nervous as I don't really body build and have no contacts there, but I've seen two reports now of complete recovery trying what you did. The other one I think the guy had PSSD for 5 years. I've had it for 14, so I gave up for a long time, but such reports are encouraging. I'm glad you recovered and don't have to suffer for years like some of us.

If it makes you feel better, we were in lockdown in Australia for 2 years straight with a few months freedom here and there. Most of my cycle wasn’t me training at all. Just being lazy at home. If it’s been 14 years it’s time to reclaim this shit back, I had it for 8ish months and was so pissed off I said fuck if whatever I need to fix this shit. Luckily it worked for me. I hope you can fix it to under guidance

Glad to hear that, how you discover this combo?

Reading around, it was all anecdotal evidence. I did have the resources and connections so I decided to give it a go.

Did you have any side effects? Did your testicles shrink?

I did get hairier on my back shoulders and traps, but I was already hairy. I did also have heightened emotions especially anger but that is a personal issue that I dealt with within the first few weeks. I couldn’t see shrinkage to be honest which concerned me about it even working but some people just don’t shrink. Especially with a “starter” cycle with just test.